RESUMO
La degeneración cerebelosa paraneoplásica es uno de los síndromes paraneoplásicos más frecuentemente asociados al cáncer, sobre todo a tumores de alta agresividad como los carcinomas de células pequeñas pulmonares, cánceres de ovarios y linfomas Hodgkin. Su fisiopatología parece deberse a una reacción inmunológica frente a las células de Purkinje del tejido cerebeloso. En la bibliografía científica actual no existen referencias a casos acontecidos en el contexto de teratomas benignos ováricos como el que presentaremos a continuación (AU)
Paraneoplastic cerebellar degeneration is one of the most frequent paraneoplastic syndromes associated with aggressive tumors such as small-cell lung cancer, gynecological cancer and Hodgkins lymphoma. The physiopathologic basis of this syndrome appears to be an immune response against Purkinje cells. Currently, there are no references in the scientific literature to cases associated with mature ovarian teratomas, as in the case presented herein (AU)
Assuntos
Humanos , Feminino , Adulto , Teratoma/patologia , Neoplasias Ovarianas/complicações , Degeneração Paraneoplásica Cerebelar/complicações , Células de Purkinje/patologiaRESUMO
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Assuntos
Humanos , Masculino , Adulto , Hamartoma/complicações , Doenças do Íleo/complicações , Doenças do Ceco/complicações , Abscesso/etiologia , Fístula Intestinal/etiologiaRESUMO
OBJECTIVE: To identify markers of response to therapy in neuroblastic tumors. STUDY DESIGN: A total of 58 patients with neuroblastic tumor (38 neuroblastomas, 13 ganglioneuroblastomas and 7 ganglioneuromas) were included in the study. TP53, BCL-2, p21Waf1/Cip1 and metallothionein were included as a biologic approach to tumor differentiation, response to therapy and prognosis. RESULTS: Patients who died of disease had the following immunophenotype: BCL-2 (9 of 10), nuclear TP53 (7 of 10) and metallothionein (7 of 10). TP-53 expression was related to clinical stage (p = 0.062) and disease outcome (p = 0.0218). All patients in whom treatment failed expressed metallothionein (3 of 3). CONCLUSION: TP53, BCL-2, p21Waf1/Cip1 and metallothionein had limited value reflecting tumor maturation (differentiation) or predicting response to therapy. Only nuclear TP53 accumulation may be relevant in patient's prognosis.
Assuntos
Biomarcadores Tumorais/metabolismo , Inibidor de Quinase Dependente de Ciclina p21/metabolismo , Metalotioneína/metabolismo , Neuroblastoma/tratamento farmacológico , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Proteína Supressora de Tumor p53/metabolismo , Adolescente , Adulto , Diferenciação Celular , Criança , Feminino , Ganglioneuroblastoma/diagnóstico , Ganglioneuroblastoma/tratamento farmacológico , Ganglioneuroblastoma/patologia , Humanos , Masculino , Neuroblastoma/diagnóstico , Neuroblastoma/patologia , PrognósticoRESUMO
No disponible
Assuntos
Feminino , Pessoa de Meia-Idade , Humanos , Leiomioma/patologia , Hormônio Liberador de Gonadotropina/efeitos adversos , Leiomioma/tratamento farmacológico , Linfócitos do Interstício Tumoral/patologia , Vasculite/patologiaRESUMO
Introducción: Se presenta una variante morfológicainusual de mieloma múltiple no secretor. Material/Método:Mujer de 37 años, con lesiones osteolíticas en pala ilíacaderecha, cráneo, mandíbula y ambas clavículas. Los estudiosde inmunoglobulinas y cadenas ligeras en sangre eran normales,y las cadenas ligeras en orina eran negativas. Resultados:El examen histológico de una biopsia de pala ilíacamuestra una proliferación de células plasmáticas con citoplasmaeosinófilo. El estudio inmunohistoquímico revelapositividad para IgG y cadena ligera lambda. Ultraestructuralmente,el citoplasma de las células plasmáticas neoplásicasse encuentra casi totalmente ocupado por mitocondrias.Conclusiones: El mieloma múltiple con cambios oncocíticoses una variante muy rara de mieloma no secretor, existiendomuy pocos casos comunicados en la literatura
Introduction: An extremely rare variant of non-secretorymyeloma is reported. Patients and methods: A 37-year-old woman presented osteolytic lesions in right ilium,skull, mandible, and both clavicles. Serum immunoglobulinsand light chains were normal. Urine light chains werenegative. Results: Histologic examination of an iliumbiopsy revealed a proliferation of neoplastic plasma cellsexhibiting eosinophilic cytoplasm. Immunohistochemicalstains showed positivity for lambda light chain and IgG.Ultrastructurally, the neoplastic cell cytoplasm was almostcompletely occupied by mitochondria. Conclusions: Multiplemyeloma with oncocytic change is an extremely rarevariant of non-secretory myeloma (only three similar caseswere found to be reported in the literature)
